Low vitamin D levels in patients with sysystemic lupus erythematous


A. Gorman, M. Doran.


Rheumatology Department, St. James's Hospital, Dublin


Low vitamin D levels have been associated with increased risk flair in patients with systemic lupus erythematous (SLE). Vitamin D deficiency is common in the general Irish population.The Irish Longitudinal Study on Ageing have shown that 13.1% of adults over the aged of 50 are vitamin D deficient in Ireland.


The aim of this study was to assess the incidence of vitamin D deficiency in a dedicated SLE clinic. We also wished to explore if vitamin D deficiency is more common in patients aged over 50 with SLE than the normal Irish population aged over 50.


Clinical notes and bloods test results were reviewed on patients attending a dedicated SLE clinic at St James’s Hospital, Dublin from May 2016 to May 2018 . Data collection included sex, age, vitamin D levels, disease stability and wether Vitamin D levels were checked after treatment.


Of the 88 patients, 58 patients had their vitamin D levels checked between May 2016 and May 2018. 8.8% (10) had vitamin D insufficiency (30–50 nmol/l) and 14.77% (13 )had deficiency (<30 nmol/l) with 35 patients having normal Vitamin D levels. Table 1 outline their demographics.

Of those with vitamin D deficiency, only one patient had their vitamin levels checked to ensure they had normalised. 15.38% of patients with vitamin D deficiency had active SLE. In comparison 14.28% of patients with normal Vitamin D had active SLE. Only 21.74% of patients with Vitamin D deficiency or insufficiency had their Vitamin D levels rechecked to ensure they had normalised.

In patients aged over 50, 30 patients had vitamin D levels check. 33 % of patients aged over 50 had vitamin D deficiency/insufficiency. with 23.3% having Vitamin D deficiency. In the patients with Vitamin D deficiency,28.5% of patients aged over 50 had active SLE.


Vitamin D deficiency was associated with a slightly higher incidence of active SLE . Vitamin D deficiency was increased in SLE patients aged over 50 compared to Irish older adult population without SLE. Patients with vitamin D deficiency aged over 50 had a higher incidence of active SLE.